High-resolution and High-speed Tomographic Imaging
Opportunity
With the growth in biomedical research and ageing populations around the world, the demand for diagnostic and tissue imaging has grown. The global tissue imaging market was estimated to be US$14.38 billion in 2019, and expected to grow at a CAGR of 8.3% to reach US$27.32 billion by 2027.
Besides imaging diseased tissue for detection, tissue imaging is in demand for the testing and cure of infectious diseases-a focus that has only heightened after the COVID-19 outbreak worldwide. There is also a need for advanced microscopy and imaging in other fields of research, such as materials science and life sciences.
However, conventional methods show limitations. These include contact with the tissue sample, long processing time for high sample volumes, or low resolutions at high tissue densities.
Technology
This novel technology-phase-shifted optical beatings of Bessel beams (PS-OB3)-based two-photon fluorescence tomography (TPFT)-offers deep tissue imaging at high speed and high resolution. The PS-OB3-based TPFT imaging method achieves this through the phase shifted optical beatings of Bessel beams, which encode the tissue volumetric information in the spatial frequency domain.
As beams tend to scatter when scanning thicker samples (resulting in low quality images), the self-reconstructing nature of Bessel beams is able to overcome this issue and provide high-resolution and high-quality imaging. The method has been proven to offer a three-fold improvement in image depth when scanning scattering media (such as fluorescent bead phantom) as compared to conventional methods like point-scan two-photon fluorescence imaging using Gaussian excitation beams.
Download
