Hydrogel System to accelerate wound healing
Opportunity
According to the World Health Organization (WHO), there are currently over 540 million adults living with diabetes and that is equivalent to 1 diabetic patient in every 10 people. Diabetic wounds are a common chronic complication of diabetes mellitus, with a lifetime risk of diabetic foot ulcer at 15 to 25% and associated lower extremity amputations.
Traditional wound dressings have limitations leading to poor wound healing efficacy, frequent recurrence and inadequate response to microenvironment changes.
The global diabetic foot ulcer treatment market was valued at USD 8.6 billion in 2021 and is expected to reach USD 14.8 billion by 2030.
Technology
This technology relates to a method to accelerate the healing of chronic diabetic wounds via the combination of the magneto-responsive hydrogel, cells and wireless magneto-induced dynamic mechanical stimulation (MDMS).
By targeting multiple pathological factors that impede wound healing, such as cell activation, collagen deposition, and neo-vascularisation, this technology has shown to promote wound closure and regulate glucose levels.
The external, contactless magneto-induced dynamic mechanical stimulation used in the hydrogel system also allows for precise control of the therapeutic doses and prevent wound recurrence.
Besides diabetic wounds, the technology has applications in other challenging wound types.
This technology has demonstrated positive results in promoting wound healing in in vitro models and diabetic mice models.
Novel combinatorial technology that harnesses the unique properties of magneto-responsive hydrogel, cells, and controllable drug delivery
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